September 2023

Answer
Atrial Flutter with far field atrial oversensing

The EGM demonstrates Atrial Flutter with far field atrial oversensing (FFAOS) and subsequent ventricular pacing (Vp) inhibition. The longest period of Vp inhibition seen on available EGMs was 8 seconds, during which a ventricular escape rhythm at ~25bpm was observed (as seen in figure 1). There had been no evidence of this finding on episode EGMs from previous pacing checks.

Investigation

The patient was asked to attend clinic the same afternoon for further investigation. A chest x-ray was performed (Fig. 2) which did not show any evidence to suggest lead fracture, insulation breach or lead displacement. An echo demonstrated no significant change from previous scans – normal LV function, normal functioning aortic valve replacement and significant bi-atrial dilatation.

Figure 2: CXR demonstrating unchanged atrial and ventricular lead placement.

Explanation

The device is programmed DDD 50 – 130/min with bipolar atrial and ventricular sensing on Automatic Gain Control (AGC) at 0.25mV in the atrium and 0.6mV in the ventricle.  The pacemaker lead trends showed high variability of R wave amplitude, ranging from 2.0 – 20.0mV, as shown in figure 3. In view of the low programmed ventricular sensitivity of 0.6mV with AGC, it is likely that the lower amplitude measurements are FFAOS signals rather than true R waves.

Figure 3: Variable ventricular intrinsic amplitude trend over 6 month period.

While we see far field R wave (FFRW) oversensing more often, FFAOS is uncommon, which is reassuring given that resulting ventricular pacing inhibition could be life-threatening for a patient with no underlying rhythm! There are few published cases on this phenomenon, but the association of FFAOS with a preceding reduction in ventricular sensitivity (Barold et al., 2002) makes the occurrence easier to understand from a programming perspective. This was evident in our case, where sensitivity was previously fixed at 2.0mV prior to boxchange and subsequently programmed to AGC 0.6mV on the new device. The issue was resolved in clinic by changing programming to fixed ventricular sensitivity of 2.5mV.

It is more difficult to understand how sensing of atrial signals on an apical RV lead can occur at all, simply due to the vast distance between the RV lead tip and the atria. Suggestions have been made in research by Martow et al. (2021) and in educational material from Ellenbogen (2020), including RV lead displacement to the AV junction / RVOT, defective insulation on the RV lead in the atrial region, presence of large muscular right atrial appendage, and atrial lead-RV lead interaction during systole. While we can exclude RV lead displacement in this case based on the chest x-ray, there was no definitive evidence which alluded to any of the other possible causes. However, normal device function has resumed with programming changes and the patient has remained symptom-free since then.

Learning points

• • Be aware of nominal sensitivity settings, particularly when changing manufacturer / model at generator replacement.
  • Consider making device less sensitive in pacemaker-dependent patients as highly sensitive programming is of low clinical utility in these patients.
  • While useful in ICD programming, consider whether auto-sensitivity programming is necessary for your pacemaker patients.

References

P wave oversensing – Cardiocases (2020) Ellenbogen K. P-wave oversensing | Cardiocases

Martow et al. (2021) Sense and Sensitivity: P wave oversensing causing inhibition in a dual chamber pacemaker and practical considerations. Heart Rhythm Society Case Reports: Volume 7, Issue 8, P546-548. Sense and sensitivity: P-wave oversensing causing inhibition in a dual-chamber pacemaker and practical considerations – HeartRhythm Case Reports

Barold et al. (2002) Far-field P-wave sensing by the right ventricular lead of conventional dual chamber pacemakers. J Interv Card Electrophysiol. 2002; 6: 77-80.